Uses, Safety, and SuitabilityPolynucleotides Explained

Rather than adding volume or altering facial structure, polynucleotides work by stimulating the skin’s own biological repair processes.

Polynucleotides are typically sourced from salmon or trout bred for human consumption, using ethical extraction and advanced purification techniques that remove proteins and impurities. This results in a biocompatible product with a strong safety profile.

You may see the terms PN, PDRN, or PN-HPT™ used when discussing DNA-based regenerative treatments, but they are not interchangeable.

• PDRN (Polydeoxyribonucleotide) refers to shorter DNA fragments, historically used in wound healing and medical regeneration.
• Polynucleotides (PN) used in aesthetic medicine are longer DNA chains with higher molecular weight, designed to provide structural support, hydration and prolonged bio-stimulation within the dermis.
• PN-HPT™ (High Purification Technology) describes a patented purification process that produces ultra-pure polynucleotides by removing proteins and impurities, improving biocompatibility and safety for injectable use.

Importantly, polynucleotides are biostimulators, not fillers. They do not create volume or contour, but instead improve hydration, elasticity and skin resilience from within.

They provide essential building blocks that help fibroblasts – the cells responsible for collagen, elastin and skin structure – function more effectively, leading to stronger, healthier skin over time.

Research shows polynucleotides can:

• Reduce oxidative stress within the dermis
• Increase fibroblast activity
• Support new collagen and elastin formation
• Improve measurable skin parameters such as hydration, elasticity and radiance

Clinical studies consistently demonstrate visible improvements in skin quality without creating an artificial or overfilled appearance.

Once injected into the dermis, they help optimise the activity of fibroblasts – the cells responsible for producing collagen, elastin and the structural components that keep skin firm, hydrated and resilient.

Rather than creating volume or altering facial shape, polynucleotides improve skin quality from within. They encourage gradual repair and renewal of the dermal environment, leading to smoother texture, improved elasticity and a healthier overall appearance.

This mechanism differs from other injectable treatments. Hyaluronic acid skin boosters primarily provide hydration, while PRP relies on growth factors derived from the patient’s own blood. Polynucleotides act directly within the tissue to support regeneration and long-term skin health.

Improvements develop progressively, with results building over a course of treatment. Many patients notice visible improvements in skin texture, hydration and firmness over 3-8 weeks as collagen production increases. Outcomes are natural-looking and cumulative, making polynucleotides well suited to patients seeking subtle, regenerative skin improvement rather than immediate cosmetic change.

They are commonly used to address early signs of ageing, skin stress and loss of resilience.

Common indications include:

• Dehydrated or chronically dry skin
• Dull or tired-looking complexion
• Fine lines and early skin ageing
• Uneven skin texture or reduced elasticity

Because polynucleotides support regeneration rather than expansion, they are particularly well suited to thin or delicate skin, including:

• Under-eye area
• Neck and décolletage

They may also be used in other clinical contexts, such as:

• Scalp treatments to support hair and scalp quality
• Scars and stretch marks
• Skin recovery following laser or energy-based procedures

Treatment can be tailored across different age groups and skin types, and polynucleotides are suitable for all Fitzpatrick skin tones when delivered by a trained medical professional following appropriate assessment.

Formulation options may include:

• Polynucleotides alone, focused on regeneration, tissue quality and skin resilience
• Polynucleotides combined with hyaluronic acid, offering regenerative support alongside additional hydration

Several established polynucleotide brands are used in UK aesthetic practice, including Plinest® and Newest®, which are CE-marked medical devices manufactured using PN-HPT® (High Purification Technology).

These products are produced under approved quality-control systems designed to ensure consistency, sterility and patient safety. Patients are encouraged to ask their practitioner which product is being used and to confirm that it meets recognised regulatory and manufacturing standards.

These treatments are commonly used across multiple areas of the face and body, including:

• Face
• Neck and décolletage
• Hands
• Scalp
• Selected body areas

As with any injectable treatment, product choice should be based on a full clinical assessment and delivered by a trained medical professional using appropriately regulated products sourced from reputable manufacturers.

The injection technique varies depending on the treatment area and indication. Common approaches include micro-droplet placement for superficial skin quality, linear threading for broader tissue support, and cannula techniques in selected areas where appropriate.

Some focus primarily on hydration, others on short-term skin plumpness, and others on supporting longer-term skin regeneration.

The table below outlines the key differences between polynucleotides and other commonly used injectable skin treatments. It is designed to help patients understand how these options compare, particularly when researching what may be considered the best skin booster UK for their individual skin concerns and goals.

Importantly, these treatments are not mutually exclusive. In clinical practice, polynucleotides are often used alongside other injectables as part of a structured skin health plan. Your practitioner will advise on the most appropriate treatment or combination based on your skin condition, medical history and desired outcome.

 

Feature	Polynucleotides (PN)	Hyaluronic Acid Skin Boosters	PRP (Platelet-Rich Plasma)	Hybrid HA Biostimulators
Primary function	Supports skin regeneration and tissue quality	Hydrates and improves skin plumpness	Delivers growth factors from patient’s own blood	Hydration with mild stimulation
Mechanism of action	Optimises fibroblast activity and dermal repair	Attracts and retains water in the skin	Stimulates repair via platelet-derived growth factors	Combines HA hydration with limited biostimulation
Effect on collagen	Encourages collagen and elastin production	Minimal direct collagen stimulation	Variable collagen response	Mild collagen stimulation
Onset of results	Gradual (weeks)	Relatively quick (days)	Gradual and variable	Moderate
Longevity of results	~6-9 months (with course)	~3-6 months	Variable between individuals	~4-6 months
Skin thickness suitability	Suitable for thin and delicate skin	Less suitable for very thin areas	Depends on technique	Area-dependent
Volume effect	None	Mild plumping	None	Mild
Downtime	Minimal	Minimal	Minimal to moderate (blood draw)	Minimal
Best for	Long-term skin quality and resilience	Hydration and short-term glow	Patients preferring autologous treatments	Maintenance and combination plans

 

Choosing the right skin booster is not about finding a single “best” treatment, but about selecting the right treatment for your skin at the right time. Polynucleotides are often preferred when the priority is improving skin quality, resilience and collagen support, particularly in delicate areas or as part of a longer-term regenerative strategy.

This approach is often referred to as dermal priming.

Dermal priming focuses on optimising skin quality, hydration and tissue resilience before treatments such as fillers, lasers or energy-based devices. By improving the condition of the dermal environment, polynucleotides may help support treatment tolerance and contribute to more consistent outcomes.

Clinical consensus supports the use of a polynucleotide priming protocol both before and after a range of procedures. When used ahead of treatment, they can help prepare the skin by supporting cellular function and hydration. When used post-procedure, they may assist with recovery and ongoing tissue repair.

Polynucleotides are commonly combined with:

• Microneedling
• Radiofrequency-based treatments
• Laser procedures, including CO2
• Selected injectable treatments

Treatment timing is carefully planned to avoid overlap and ensure each modality can work effectively. Your practitioner will advise on appropriate spacing and sequencing based on your skin condition and overall treatment plan.

Used in this way, polynucleotides form part of a structured, regenerative approach to skin health rather than a standalone cosmetic treatment.

This typically includes doctors, nurses, dentists or prescribing pharmacists working within a regulated clinical setting.

Before proceeding with treatment, a full consultation should be carried out to assess your skin concerns, medical history and suitability. Your practitioner should be able to clearly explain the product being used, the treatment plan and what results to expect.

When choosing a clinic or practitioner, it is sensible to check that:

• The practitioner is medically qualified and appropriately trained in injectable treatments
• CE-marked, regulated products from reputable manufacturers are being used
• The clinic follows UK regulatory guidance and professional standards
• Clear aftercare advice and follow-up support are provided

Patients should be cautious of heavily discounted treatments or providers who are unable to confirm product origin, training credentials or safety standards. Injectable treatments carried out outside of a medical framework may increase the risk of complications and poor outcomes.

Choosing an experienced, properly trained practitioner helps ensure that polynucleotide treatments are delivered safely, ethically and with appropriate clinical oversight.

Before treatment:

• Full skin assessment and discussion of treatment goals
• Explanation of the product being used and expected outcomes
• Opportunity to ask questions and give informed consent

On the day of treatment:

• Skin is cleansed and prepared
• Topical anaesthetic cream may be applied for comfort
• Polynucleotides are injected into the dermis using a fine needle or cannula
• Treatment typically takes 30-45 minutes

Immediately after treatment:

• Mild redness, swelling or small injection marks may be visible
• These effects usually settle within 24-48 hours
• Most patients can return to normal daily activities the same day

 Treatment course and timing:

• Usually delivered as a course of 3-4 sessions
• Sessions spaced 3-4 weeks apart
• Improvements build gradually over the following weeks

Many patients notice early improvements in hydration and skin texture, with more visible changes developing as collagen production increases over time.

Results develop progressively as the skin responds to treatment and regenerative processes are supported.

Typical timeline of results:

• Around 2 weeks: improved hydration and skin comfort
• Around 4 weeks: smoother texture and increased radiance
• Around 8 weeks: visible improvements in elasticity, firmness and overall skin quality

As collagen and elastin production continue to be stimulated, results may continue to improve over the following months, particularly after completion of a full treatment course.

Commonly reported outcomes include:

• More hydrated, supple skin
• Improved skin texture and smoothness
• Reduction in the appearance of fine lines
• Healthier, more even-looking skin

Because results build over time, before-and-after images are typically taken several weeks apart and after a full course of treatment. These images help demonstrate improvements in skin quality rather than changes in volume or facial shape.

Maintenance treatments may be recommended to help sustain results, and outcomes can vary depending on skin condition, age, lifestyle factors and adherence to the treatment plan.

Your practitioner will provide personalised guidance, but general recommendations typically include the following.

Immediately after treatment:

• Avoid applying makeup for 24 hours
• Avoid strenuous exercise, saunas and steam rooms for 24-48 hours
• Refrain from touching or massaging the treated area unless advised

Ongoing skin care:

• Use gentle, non-active skincare products for several days
• Apply broad-spectrum SPF daily to protect the skin
• Maintain good hydration to support skin repair

Polynucleotide treatments are designed to support long-term skin quality rather than provide a short-term cosmetic effect. To maintain results, many patients choose to have maintenance treatments every 6-9 months, depending on skin condition, age and lifestyle factors.

Healthy habits such as adequate sleep, sun protection, balanced nutrition and avoiding smoking can also help prolong results by supporting collagen production and overall skin health.

Your practitioner will advise on the most appropriate maintenance plan based on how your skin responds to treatment and your long-term goals.

As with any injectable procedure, some temporary side effects can occur.

Common, mild side effects may include:

• Redness at the injection sites
• Mild swelling or tenderness
• Small areas of bruising

These effects are usually short-lived and settle within 24-72 hours without intervention.

Products such as Plinest®, which are manufactured using high-purification processes and produced under approved quality-control systems, have demonstrated a strong safety profile in both clinical use and published literature.

The advanced purification of polynucleotides reduces the risk of allergic reactions and improves biocompatibility with human tissue.

Strict sterile technique, appropriate patient selection and correct injection depth are essential to minimise risk. Your practitioner should provide clear aftercare advice and explain what to expect following treatment.

Patients are advised to contact their practitioner if swelling, redness or discomfort persists beyond the expected timeframe, or if they have any concerns following treatment.

Most patients are advised to undertake a course of treatments, usually 3-4 sessions spaced several weeks apart, to achieve optimal results. Some clinics offer course pricing, which may reduce the overall cost compared to paying per session.

Pricing can vary based on several factors, including:

• The specific polynucleotide product used
• The size and number of areas treated
• The practitioner’s level of training and expertise
• The clinical setting and aftercare provided

When comparing prices, it’s important to consider quality and safety rather than cost alone. Lower-priced treatments may use less well-regulated products or be delivered outside of a medical framework, which can increase the risk of complications and reduce treatment effectiveness.

While polynucleotide treatments may represent a higher upfront investment than some skin boosters, many patients consider them good value due to their regenerative benefits and longer-term improvements in skin quality. Some clinics may also offer staged payment options or treatment plans to spread the cost.

Clinical studies and consensus reports consistently demonstrate improvements in skin quality, hydration and elasticity following treatment.

Published research has shown that polynucleotide-based treatments can:

• Improve dermal hydration and skin elasticity
• Support collagen and elastin production
• Enhance overall skin texture and radiance
• Deliver visible improvements without creating volume

Importantly, studies report a strong safety profile, with no serious adverse events when treatments are performed using purified products and appropriate clinical technique. This is particularly relevant for high-purification formulations such as those used in established products like Plinest®, which have been evaluated in both clinical practice and peer-reviewed literature.

Expert consensus within aesthetic medicine increasingly recognises polynucleotides as a regenerative option suited to improving skin quality, supporting dermal repair and preparing the skin for other treatments as part of a structured plan.

While individual results vary, the existing evidence supports the use of polynucleotides as a safe and effective approach for patients seeking gradual, natural-looking improvements in skin health.

Ethical manufacturers use controlled sourcing methods that ensure materials are obtained responsibly and without unnecessary waste.

High-quality polynucleotide products undergo rigorous purification processes designed to remove proteins and impurities, resulting in a biocompatible material suitable for injectable use. This focus on purification not only supports safety but also reflects responsible manufacturing standards.

Established brands such as Plinest® are produced under approved quality-management systems, with traceability across sourcing, purification and manufacturing. This helps ensure consistency, sterility and compliance with recognised regulatory requirements.

As interest in sustainability grows within aesthetic medicine, manufacturers continue to explore improvements in environmental responsibility, transparency and production efficiency. Patients are encouraged to ask their practitioner about product origin, manufacturing standards and ethical considerations when choosing treatment.

“Polynucleotides are fillers.”
Polynucleotides are not dermal fillers. They do not add volume, contour the face or change facial structure. Instead, they work by supporting skin regeneration and improving tissue quality over time.

“They’re new and untested.”
Polynucleotides have been used in medical and regenerative settings for decades. Their application in aesthetic medicine builds on an established scientific and clinical foundation.

 “They’re made from human DNA.”
Aesthetic polynucleotides are derived from purified fish DNA, typically salmon or trout bred for human consumption. Advanced purification processes remove proteins and impurities, resulting in a biocompatible product suitable for injectable use.

“They work instantly.”
Polynucleotides are designed to deliver gradual improvement, not immediate cosmetic change. Results develop over weeks and continue to improve as collagen and elastin production is supported.

“They’re unsafe for delicate areas.”
When delivered by a trained medical professional using appropriately regulated products, polynucleotides are widely used in delicate areas such as the under-eye region and neck due to their non-volumising nature.

Understanding what polynucleotides can – and cannot – do helps set realistic expectations, deliver safe results and ensure treatments are chosen for the right reasons.