How It Works and Who It Is Suitable ForPlinest® by DermaFocus?

Plinest® is a next-generation bioregenerative injectable treatment designed to improve skin quality from within. Developed by Mastelli S.r.l. in Italy and distributed exclusively in the UK by DermaFocus, it uses a clinically proven technology called PN-HPT® (Polynucleotides High Purification Technology).

Plinest® is not a filler or a botulinum toxin. Instead of adding volume or reducing muscle contraction, it helps your skin regenerate naturally – improving hydration, elasticity, firmness, texture, fine lines, and scars.

The Plinest® family includes:

• Plinest® – for full-face and body rejuvenation
• Plinest® Eye – for delicate under-eye skin
• Plinest® Hair – for scalp and eyebrow bioregeneration

Plinest® is a CE-marked medical device, ensuring high standards of safety and quality.

Plinest® uses PN-HPT® (Polynucleotides High Purification Technology) – the manufacturer’s patented process that produces ultra-pure DNA fragments designed to repair and regenerate the skin.

What Plinest does®

Polynucleotides are naturally derived DNA molecules that act as regenerative messengers. Once injected, they help the skin:

• Activate fibroblasts (the cells that make collagen and elastin)
• Repair damaged tissue
• Improve hydration and elasticity
• Reduce inflammation and oxidative stress

They essentially help the skin behave more like youthful, healthy tissue.

The high purification process used by Mastelli (the Plinest® manufacturer) removes proteins and impurities, to ensure that Plinest® is:

• Extremely safe and biocompatible
• Suitable even for delicate areas like the eyes and the scalp
• Consistent, stable and clinically reliable

Many newer polynucleotides products contain low concentrations or less purified molecules. Plinest® contains clinically validated doses backed by decades of medical research.

How Plinest® regenerates skin

Plinest® delivers three key regenerative actions that work together to rebuild healthier, stronger and more resilient skin from within:

1. Collagen and elastin renewal
Stimulates fibroblasts to rebuild structure, firmness and elasticity.

2. Deep biological hydration
Plinest® binds and holds water within the tissue for smoother, more supple skin.

3. Antioxidant and repair support
Neutralises free radicals and supports healthy skin turnover.

The result

After using Plinest®, skin becomes stronger, smoother, brighter and more resilient, with improvements that look completely natural.

Plinest® works by activating the skin’s natural repair systems. Its ultra-pure polynucleotides send targeted signals that encourage the skin to regenerate itself more effectively and behave more like youthful, healthy tissue – it’s like giving your skin new blueprints for regeneration.

Fibroblast stimulation

Plinest® helps activate and multiply fibroblasts – the cells that produce collagen, elastin and hyaluronic acid. This strengthens the skin’s structure, improves firmness and reduces fine lines over time.

DNA repair signalling

The polynucleotides in Plinest® act as biological messengers, supporting healthy cell turnover and encouraging damaged cells to repair themselves more efficiently.

Deep hydration

Polynucleotides attract and bind water within the tissue, giving the skin long-lasting hydration and helping it feel smoother, plumper and more supple.

Antioxidant activity

Plinest® helps neutralise free radicals from environmental stressors such as UV exposure and pollution, contributing to a healthier, brighter-looking complexion.

Support for healthier skin tissue

By improving the environment around the cells, Plinest® helps the skin function more effectively, promoting stronger, better-organised tissue and a more even texture.

Skin priming before other procedures

The regenerative boost from Plinest® makes it an ideal skin-priming treatment before microneedling, laser, RF, surgery or fillers, helping to support better outcomes and smoother healing.

The result

Clinical studies have shown:

• +21% increase in elasticity
• +14% increase in hydration
• 91% of patients reported visible improvement

In general, skin becomes firmer, healthier, more hydrated and more radiant – improved from the inside out through regeneration rather than added volume.

Plinest® is suitable for men and women who want to improve their overall skin quality and support healthier, more resilient tissue.

It can benefit people experiencing:

• Early signs of ageing
• Dullness or lack of luminosity
• Dryness or dehydration
• Fine lines and crepey skin
• Sun damage and uneven tone
• Mild to moderate acne scarring
• Loss of firmness or elasticity
• Textural changes on the face, neck or body

Plinest® Eye

 Designed specifically for the delicate periocular area, Plinest® Eye can help improve:

• Dark circles
• Thin, fragile under-eye skin
• Fine lines
• Crepiness

 Plinest® Hair

Plinest® Hair supports scalp and follicle health and is suitable for both men and women experiencing:

• Menopausal or hormonal thinning
• Stress-related shedding
• Weak or brittle eyebrow hair
• Early-stage hair density changes

Who should avoid Plinest®

Plinest® is not recommended for individuals who are:

• Pregnant or breastfeeding
• Experiencing active infection in the treatment area
• Living with uncontrolled autoimmune disorders
• Allergic to fish
• Undergoing treatment for active cancer

A qualified medical practitioner will assess suitability during consultation.

Plinest® is a versatile regenerative treatment used on the face, neck and body to enhance overall skin quality. By supporting natural repair processes, it can address a wide range of concerns commonly linked to ageing, lifestyle and environmental stressors.

Fine lines and wrinkles

Plinest® helps improve the appearance of early fine lines and more established wrinkles by stimulating fibroblast activity and supporting collagen and elastin renewal. This results in smoother, firmer, more youthful-looking skin without adding artificial volume.

Dull or photo-aged skin

When skin lacks brightness or has become coarse due to sun exposure or ageing, Plinest® encourages healthier cell turnover and improved hydration. This helps restore a fresher, more radiant complexion and visibly softens dryness and roughness.

Smokers’ lines and dehydration

Vertical lines around the mouth, often linked to repetitive movement or dehydrated tissue, respond well to Plinest®. Its water-binding and regenerative properties help increase tissue density and smooth the appearance of fine creases.

Hyperpigmentation and uneven tone

While not a direct pigmentation treatment, Plinest® supports healthier skin turnover and improves the surrounding tissue quality. Over time, this can help the complexion appear more balanced, even and refined.

Loss of firmness and elasticity

As collagen levels decline, the skin can feel thinner or less resilient. Plinest® helps activate fibroblasts to rebuild structural proteins, improving firmness, bounce and overall skin strength.

Acne scars

By stimulating collagen remodelling, Plinest® gradually softens the look of pitted or uneven acne scars, helping to smooth texture and improve uniformity across the treated area.

Plinest® offers several formulations designed for different areas and concerns. Each uses PN-HPT® but varies in concentration and volume to suit specific treatment zones.

Plinest® (40 mg / 2 ml)

A versatile, higher-strength formulation for the face, neck, décolleté, hands and body. Ideal for boosting hydration, firmness, elasticity and overall skin quality.

 Plinest® Eye (15 mg / 2 ml)

A gentler, lower-concentration treatment created for the delicate under-eye area. Helps improve dark circles, crepiness, thin skin and early fine lines without adding bulk.

Plinest® Hair (15 mg / 2 ml)

Designed for the scalp and eyebrows, this formulation supports follicle health and tissue quality. Suitable for early hair thinning, menopausal shedding, stress-related hair changes or general scalp rejuvenation.

 Newest® (20 mg PN-HPT® + 20 mg hyaluronic acid / 2 ml)

A combined formulation that pairs PN-HPT® with hyaluronic acid for both regenerative benefits and enhanced hydration. Useful for areas needing additional moisture alongside tissue repair.

Recommended treatment plan

Most people benefit from 3-4 sessions, spaced 3 to 4 weeks apart, followed by maintenance appointments every 3-6 months.

A trained medical practitioner will recommend the best product and plan for your individual goals.

A Plinest® treatment is quick, comfortable and designed to fit easily into your regular skin maintenance routine. Your practitioner will guide you through each step to ensure a smooth and safe experience.

Step 1: Consultation and preparation

Your practitioner assesses your skin, discusses your goals and selects the appropriate Plinest® formulation. The skin is then thoroughly cleansed, and a numbing cream may be applied for comfort.

Step 2: Precise injection technique

Plinest® is placed into the skin using one of two common methods:

• Microdroplet technique: tiny droplets are placed just under the surface of the skin for even distribution.
• Linear retrograde technique: small threads of product are deposited as the needle or cannula is gently withdrawn, creating smooth, continuous placement.

A needle or cannula may be used depending on the area being treated, your skin concerns and your practitioner’s clinical preference.

Step 3: Immediate after-effects

You may notice mild swelling, redness or small bumps where the product was placed. These effects are normal and usually settle within 24-48 hours.

Step 4: Gradual improvements

Early improvements in hydration and texture often appear within 2-4 weeks as the skin begins to regenerate.

Step 5: Optimal results

The most noticeable changes – including improved firmness, smoothness and overall quality – develop around 3 months, once collagen and elastin regeneration peaks.

Plinest® delivers gradual, natural-looking improvements as the skin regenerates and strengthens from within. Results build over time rather than appearing all at once, giving a refreshed and healthy appearance without adding volume.

Immediately after treatment

You may notice a subtle boost in hydration and a gentle glow once any initial redness or swelling settles.

After 2-4 weeks

Early changes become visible as the skin begins to repair and replenish itself. Texture may feel smoother, and areas of dryness or dullness often improve.

Around 3 months

This is when collagen and elastin regeneration peaks, delivering the most noticeable results. Skin typically appears firmer, more even, more elastic and overall healthier.

How long results last

Most people enjoy improvements for 6-9 months, depending on skin type, lifestyle and the area treated.

Maintenance sessions once or twice a year help keep results at their best.

Plinest® is often compared with other injectable treatments, but it works in a different way. Instead of adding volume or simply boosting hydration, Plinest® supports the skin’s natural regeneration, helping it function more like youthful, healthy tissue.

Plinest® vs Profhilo®

Both Plinest® and Profhilo® are injectable treatments that aim to refresh the skin, but they work through different mechanisms:

• Profhilo® is a stabilised hyaluronic acid treatment designed to deeply hydrate the skin and give it a dewy, smoother appearance.
• Plinest® uses highly purified polynucleotides to encourage the skin to repair, strengthen and renew itself over time.

In simple terms: Profhilo® hydrates. Plinest® regenerates.

Many people choose to use both treatments at different times depending on their goals.

Plinest® vs PRP

PRP (platelet-rich plasma) uses a patient’s own blood to stimulate healing and regeneration. While effective, results can vary because the quality of PRP depends on the individual.

Plinest® offers:

• Consistent, standardised results
• A sterile, laboratory-controlled formulation
• No variability between treatments

This makes Plinest® a reliable option for those who prefer a predictable outcome or are not suitable candidates for PRP.

Quick comparison

Treatment	What it does	How it works	Best for
Plinest®	Regenerates and strengthens skin	Pure polynucleotides stimulate repair	Skin quality, elasticity, scars, crepiness
Profhilo®	Deep hydration	Hyaluronic acid spreads through the tissue	Dewiness, glow, hydration boost
PRP	Regeneration (variable)	Uses your own plasma	Hair growth, general rejuvenation

Plinest® Hair is a regenerative injectable designed to support scalp health, follicle function and hair quality in both men and women. It uses the same PN-HPT® technology as the facial formulations but is optimised for the needs of the scalp.

What Plinest® Hair can help with

Plinest® Hair is suitable for those experiencing:

• Early-stage thinning in men and women
• Menopausal or postpartum hair changes
• Stress-related shedding
• Weak, brittle or sparse eyebrow hair
• Reduced scalp quality, dryness or sensitivity

It can be used on the scalp, hairline and eyebrows, depending on your goals.

How it works

Plinest® Hair supports a healthier environment around the follicles by helping to:

• Improve trophism (the nourishment and support around each follicle)
• Extend the anagen phase (the active growth stage of the hair cycle)
• Support tissue repair and overall scalp condition
• Reduce dryness or tightness in the treated area

A healthier scalp leads to stronger-looking, more resilient hair over time.

Clinical insights

In observational data, 72% of women reported visible improvement after four months of treatment, including better density, reduced shedding and stronger-looking strands.

The treatment plan

A typical course involves 8 sessions, delivered in two phases:

• Phase 1: Weekly sessions for the first four weeks
• Phase 2: Monthly sessions for the following four months

Your practitioner may combine Plinest® Hair with other hair-restoration approaches such as PRP, LED therapy or topical treatments, depending on your needs.

Plinest® should only be administered by qualified medical professionals who are trained in regenerative injectables and understand the anatomy of the areas being treated.

You should look for a:

• Doctor
• Dentist
• Nurse prescriber

These practitioners have the clinical expertise to assess your suitability, choose the correct Plinest® formulation and deliver treatment safely.

For help finding a practitioner who offers Plinest®, you can contact DermaFocus, the official UK and Ireland distributor, who can direct you to authorised clinics.

Or use our Clinic Finder to search for a Plinest® clinic in your area.

The cost of Plinest® varies depending on the clinic, the practitioner’s experience, the area being treated and whether you choose a package of sessions.

Typical prices in the UK are:

• Plinest®: £250-£400 per session
• Plinest® Eye: £200-£350 per session
• Plinest® Hair: £250-£450 per session

Many clinics offer packages of 3-4 sessions, which can provide better value and are often recommended for optimal results.

Maintenance sessions are usually advised once or twice a year to keep results looking their best.

For specific pricing or to find an authorised practitioner, you can contact DermaFocus for guidance. Call 02039941666 or email info@dermafocus.co.uk

Plinest® is known for its excellent safety profile, thanks to the high level of purification used in PN-HPT®. It is biocompatible, well-tolerated and suitable for even delicate areas such as the under-eyes.

Most side effects are mild and temporary, and may include:

• Redness at the injection points
• Swelling or puffiness in the treated area
• Small bumps where the product was placed
• Mild bruising, depending on the area and technique

These typically resolve within 24-48 hours.

No serious adverse reactions have been reported in clinical studies when Plinest® is used correctly by trained medical professionals.

Your practitioner will discuss your medical history, assess suitability and provide tailored aftercare advice to help you achieve the best results safely.

Plinest® requires minimal downtime, but following simple aftercare steps will help your skin recover smoothly and support the best possible results.

Immediately after treatment

For the first 24 hours, it’s recommended to:

• Avoid touching or rubbing the treated area
• Skip heavy exercise, saunas and steam rooms
• Avoid alcohol, which can increase redness or swelling
• Delay applying makeup for 6-12 hours

General aftercare

 Over the next 48 hours, you should:

• Keep the area clean and well-hydrated
• Avoid direct sun exposure
• Use a high-factor SPF daily
• Follow any personalised advice from your practitioner

Maintenance

To keep results looking their best, most people have:

• A full course of 3-4 sessions, followed by
• Maintenance treatments every-6 months, depending on your goals and how your skin responds

Your practitioner will recommend the most suitable schedule based on your skin type, lifestyle and the area treated.