In the ever-evolving landscape of medical aesthetics,
Neauvia emerges as a revolutionary force with its PEG-HA Fillers, setting a new standard in the hyaluronic acid (HA) filler market. The hallmark of Neauvia fillers lies in their groundbreaking Smart Crosslinking Technology (SXT), a patented innovation seamlessly blending hyaluronic acid and polyethylene glycol (PEG) into a cohesive network. This convergence of science and artistry creates a unique synergy that distinguishes Neauvia from the rest.
Distinguished by its polyethylene glycol diacrylate (PEGDE) crosslinking, Neauvia’s technology boasts diverse molecular weights and chain lengths.1 This results in high conformational flexibility and shape modification without structural damage, setting the stage for a remarkable transformation in the world of aesthetic procedures.
Why PEG?
Neauvia’s strategic choice of PEG sets it apart, offering distinctive properties that elevate the efficacy of its gels to unprecedented levels. The gels exhibit high viscoelasticity and cohesivity, mirroring the mechanical properties of natural skin tissues. The immediate results achieved through Neauvia’s PEG-HA Fillers, combined with thermo-dynamic and thermo-stability properties, allow for the implementation of versatile and effective combined protocols.
Ensuring a High-Safety Profile, Neauvia’s fillers stand out with no pathologic inflammatory reactions* and no residual remains.1 The reversible filling aspect adds an extra layer of confidence, embodying Neauvia’s commitment to safety and patient satisfaction.
“Neauvia’s fillers are currently the only injectable products based on Hyaluronic Acid crosslinked with PEG that have been tested in vivo and in vitro, demonstrating favourable clinical results. Thanks to PEG, which gives Neauvia’s hydrogels unique rheological properties, you can have combined protocols through a synergistic approach.”
Prof. Nicola Zerbinati, dermatologist and Neauvia Scientific Director, Italy
Neauvia’s Research and Development team has meticulously crafted monophasic and cohesive hydrogels, showcasing distinctive properties and gel consistencies. The patented Smart Crosslinking Technology (SXT) integrates different molecular weights and chain lengths, influencing the product’s behaviour under mechanical stress during injection and throughout its life in the tissues.
From formulation to results, Neauvia’s commitment to excellence is evident. Each filler in Neauvia’s line is enriched with proteinogenic amino acids, Glycine and L-Proline, integral to the biosynthesis of proteins.2 These amino acids contribute to fine-tuning the rheological properties and swelling resistance, ensuring better control of the hydrogel’s swelling capacity in the post-implant phase.3
For those seeking a paradigm shift in medical aesthetics, Neauvia beckons you to explore its innovation at Neauviachannel.com. Join us in rethinking medical aesthetics and discover the transformative potential of Neauvia PEG-HA Fillers, where science meets art to redefine beauty.
References
*None detected so far with the use of Neauvia PEG-HA Fillers.
1. Clinical data on file
2. Zerbinati, N.; Sommatis, S.; Maccario, C.; Capillo, M.C.; Grimaldi, G.; Alonci, G.; Protasoni, M. Rauso, R.; Mocchi, R. Toward Physicochemical and Rheological Characterization of Different HA Dermal Fillers Cross-Linked with Polyethylene Glycol Diglycidyl Ether. Polymers 2021, 13, 948
3. Marino F, Cosentino M, Legnaro M,et al. Immune profile of hyaluronic acid hydrogel polyethylene glycol crosslinked: An in vitro evaluation in human polymorphonuclear leukocytes.
4. Zerbinati, N.; Capillo, M.C.; Sommatis, S.; Maccario, C.; Alonci, G.; Rauso, R.; Galadari, H.; Guida, S.; Mocchi, R. Rheological Investigation as Tool to Assess Physicochemical Stability of a Hyaluronic Acid Dermal Filler Cross-Linked with Polyethylene Glycol Diglycidyl Ether and Containing Calcium Hydroxyapatite, Glycine and L-Proline. Gels 2022, 8, 264.
5: Zerbinati N, Lotti T, Monticelli D, Martina V, Cipolla G, D’Este E, Calligaro A, Mocchi R, Maccario C, Sommatis S, Lotti J, Wollina U, Tchernev G, França K. In Vitro Evaluation of the Sensitivity of a Hyaluronic Acid PEG Cross - Linked to Bovine Testes Hyaluronidase. Open Access Maced J Med S
