Juvéderm® HYDRATE

Product Summary


Juvéderm® HYDRATE is part of the Juvéderm® ULTRA family of dermal fillers which contain hyaluronic acid (HA) as well as the anti-oxidant, mannitol.

Juvéderm® HYDRATE is designed to improve skin hydration and elasticity by replacing HA lost through ageing. It is not a traditional filler; instead it acts as a hydrating agent, attracting moisture, retaining it within the skin to maintain a healthy glow. It is administered as tiny injections to the face, neck, hands and décolletage.

Juvederm Hydrate was launched in the UK and Europe in 2010 and is manufactured and distributed by Allergan, the maker of the Juvéderm® filler range and the botulinum toxin, Botox®.

Generic name

Cross-linked hyaluronic acid with mannitol.

What does it contain?

Juvéderm® HYDRATE uses a non-animal form of hyaluronic acid, plus mannitol, an antioxidant which helps to fight potentially damaging free radicals. Free radicals can deteriorate hyaluronic acid and the inclusion of an antioxidant helps to prolong the results of the treatment.

How is it made?

Streptococci bacterial fermentation. Mannitol is a naturally-derived antioxidant.

Is a skin test required before treatment?

No allergy test needed.

Is it temporary or permanent?

Hyaluronic acid is completely broken down within the skin over a period of months, eventually leaving no trace of the filler. This treatment typically lasts for between four and six months.

Licenced status

Juvéderm® HYDRATE is classed as a CE marked medical device having been given a European CE mark in December 2009.

Should be used by

Trained members of the medical profession only, including doctors, nurses and dentists.

Product range

Juvéderm® HYDRATE is available in one formulation and has a number of applications:

Juvéderm® HYDRATE (13.5mg hyaluronic acid, 9mg mannitol/ml)


Juvéderm® HYDRATE is not a traditional filler. It is used to improve elasticity, hydration and skin laxity and is used in a treatment technique known as mesotherapy, whereby the product is superficially injected in minute quantities into the upper layers of skin, improving hydration, resulting in a smooth, bright, natural appearance. Hyaluronic acid is a humectant, which means that it attracts and retains up to 1,000 times its own weight in water. When used in mesotherapy, it draws in moisture and retains it, reducing the dryness, fine lines and wrinkles associated with ageing and is also recommended as an early treatment for crow’s feet and fine lines around the mouth.

Not to be used in

Juvéderm® HYDRATE should not be used in clients with the following contra-indications.

• those with allergies or known intolerant reactions to hyaluronic acid or mannitol,
• those with skin inflammation or allergies,
• those who are susceptible to hypertrophic scarring,
• those who are pregnant or breastfeeding women,
• or those taking certain medications, including antibiotics and chemotherapy.

Duration of effect

The effects of Juvéderm® HYDRATE last for approximately four to six months. This is a shorter period of time than other injectable treatments, and this is because the product is injected superficially rather than deep into the dermis like other dermal filler products.

Reported side effects

Transient erythema (redness), swelling, pain, itching, discolouration or tenderness at the injection site.


This depends on the area treated and how much is required, and the practitioner doing the treatment, but price ranges are in the region of £150 - £400.

Clinical Data

In a recent study*, 95% of patients were delighted with the results of their treatment with Juvéderm® HYDRATE, and 85% said that they would recommend the treatment to a friend. The majority of practitioners were also impressed with Juvéderm® HYDRATE, as they graded skin hydration as significantly improved at day 60 and found it easy or very easy to inject. 

 *Hyaluronic acid plus mannitol treatment for improved skin hydration and elasticity. Taieb M. AMWC Monte Carlo 2010.


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