27
Jan
2026
Polynucleotides have quickly become one of the most in-demand regenerative treatments in the UK – and two names stand out: Plinest® and Newest®. Both come from Mastelli, the Italian pharmaceutical company behind PN-HPT™ (Polynucleotides High Purification Technology), but they have slightly different purposes.
What Plinest® and Newest® Have in Commonc
Both injectables use ultra-pure, highly biocompatible polynucleotides that help the skin regenerate itself. They support fibroblast activity, hydration, collagen renewal and overall skin quality.
The Main Difference: Ingredients
Plinest®: Pure PN-HPT™ polynucleotides: best for regeneration, elasticity, firmness and improving thinning or crepey skin.
Newest®: PN-HPT™ plus hyaluronic acid: offers added hydration alongside regeneration.
Who Should Choose Plinest®?
Who Should Choose Newest®?
Can They Be Used Together?
Many practitioners combine both treatments in different areas, depending on the patient’s needs and skin condition.
The Bottom Line
If you want pure regeneration, choose Plinest®. If you want regeneration + hydration, choose Newest®.
Ready to take the next step in your polynucleotide journey?
Whether you’re curious about how these treatments work, want answers to specific questions, or are ready to book your appointment, we’ve got you covered.
To find your nearest qualified clinic and trusted polynucleotide practitioners, click here: https://www.consultingroom.com/treatments/polynucleotides/#find-a-verified-clinic
Your skin deserves expert care — and we're here to help you make an informed choice.
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