Mastelli: Over 70 Years of Regenerative Expertise
Mastelli’s legacy in polynucleotide science dates back to the 1950s. As pioneers in regenerative medicine, they have developed and refined their polynucleotide formulations over decades of work in:
- Dermatology
- Wound healing
- Ophthalmology
- Regenerative medicine
- Tissue repair therapies
This longstanding scientific commitment is the foundation of the Plinest® range, which is now widely used across Europe and beyond.
Mastelli’s involvement in both laboratory research and clinical development ensures Plinest® is not simply a cosmetic product, but a pharmaceutical-grade regenerative therapy backed by real-world evidence.
The Science Behind Plinest®
Plinest® is powered by PN-HPT® (polynucleotide high purification technology) –Mastelli’s patented process that delivers ultra-pure, biocompatible DNA fragments.
What makes PN-HPT® unique?
PN-HPT® removes proteins and impurities, creating polynucleotides that are:
- Highly purified
- Extremely well tolerated
- Suitable for delicate areas (including under the eyes)
- Consistent and reliable in clinical use
This level of safety and purification is one of the factors that distinguishes Plinest® from generic or unregulated PN products entering the market.
Evidence-Led, Clinically Proven
Plinest® is supported by clinical studies researching improvements in:
- Hydration
- Elasticity
- Smoothness and texture
- Fine lines
- Skin density
- Under-eye quality
- Tissue repair and restructuring
In these studies, Plinest® has demonstrated measurable outcomes such as:
- +21% improved elasticity
- +14% increased hydration
- 91% patient-reported improvement
This makes Plinest® one of the most well-documented polynucleotide injectables currently available.
DermaFocus: Bringing Safe Regeneration to UK and Ireland
While Mastelli develops and manufactures Plinest®, DermaFocus ensures that the product is introduced, distributed and used properly within the UK and Irish aesthetic community.
What DermaFocus ensures:
- Medical-grade distribution only
Plinest® is supplied exclusively to trained, qualified medical professionals. - Consistent practitioner training
Practitioners receive approved education on techniques, safety, clinical applications and product handling. - Authentic product assurance
Clinics receive genuine Mastelli formulations with full traceability and correct storage conditions. - Clinical governance and guidance
DermaFocus supports practitioners with ongoing education, safety updates and product expertise.
This ensures that Plinest® is delivered exactly as intended – safely, responsibly and in line with the manufacturer’s standards.
Why This Partnership Matters
In an industry that is rapidly growing, and where not all products meet the same quality standards, the Mastelli x DermaFocus partnership provides reassurance built on:
- Scientific credibility
- Pharmaceutical standards
- Ethical, controlled distribution
- High practitioner training
- Commitment to patient safety
Patients benefit from both Mastelli’s deep scientific heritage and DermaFocus’s responsible, clinician-focused approach to bringing regenerative treatments to the UK and Ireland.