Focused Cold Therapy™, generically known as cryoneuromodulation is a new non-invasive treatment designed to improve the appearance of fine lines and facial wrinkles using highly pressurised nitrous oxide. Specifically targeted towards patients who are uncomfortable with the idea of using botulinum toxins (e.g., Botox) to smooth out wrinkles, cryoneuromodulation is essentially a toxin-free way that is being marketed to achieve a wrinkle-free appearance in the forehead and frown areas, utilising the power of cold, rather than the power of a neurotoxin. Currently, there is only one cryoneuromodulation product being actively marketed for this type of treatment, called Iovera® and made by Myoscience Inc, who have patented the therapy and trademarked the concept of Focused Cold Therapy™. Focused Cold Therapy™ with Iovera® costs approximately £300 for a 15 minute session. The treatment is in its early stages of use and is not currently widely available in the UK.