Everything You Need to Know About Exosomes and Exosome Rejuvenation

Exosomes are gaining traction as they represent the next level of regenerative medicine – according to Corina Mihalache, expert aesthetician and founder of Ace Skin Health Clinic, who offers Exosome Rejuvenation Treatment at her clinic.

Below, Corina answers our Exosome questions and reveals more about the Exosome Rejuvenation Treatment and its benefits.

What are Exosomes and why is everyone talking about them?

Exosomes are naturally secreted stem cell vesicles that act as cellular messengers. They contain powerful proteins, growth factors, peptides, cytokines and mRNA that facilitate cellular communication. We use E-50 exosomes, which are derived from salmon embryonic stem cells and contain a rich mixture of growth factors, peptides, amino acids, lipids and genetic material. They are gaining attention because they represent the next level of regenerative medicine. They offer natural skin rejuvenation by working with the body's own healing mechanisms, which is why they are causing such a stir among beauty insiders and professionals.

Do Exosomes need to be administered by a professional or can I add them to my skincare regime?

Exosomes used in professional treatments must be administered by a trained aesthetician or medical professional to ensure optimal penetration, safety and efficacy. While some skincare brands are beginning to incorporate exosomes into products for home use, these formulations often lack the high concentration and targeted delivery system required for deep skin rejuvenation. In-clinic treatments ensure maximum absorption and cellular response and deliver better results compared to topical applications.

What is the Exosome Skin Rejuvenation treatment and how are exosomes applied?

Our treatment combines exosomes with advanced delivery methods. We apply exosomes during microneedling or RF microneedling to improve absorption and penetration. We then use our TargetCool device, which utilises a cold CO2 spray with even more exosomes to enhance delivery while soothing the skin and supporting faster recovery. These methods allow the exosomes to penetrate deep into the skin, stimulating regeneration, promoting collagen synthesis and accelerating skin healing for a visibly youthful and revitalised complexion.

How long is the treatment?

The treatment usually takes about 60-90 minutes, depending on the method used, including preparation and aftercare discussion.

Who should have Exosome Skin Rejuvenation, and for whom is it good?

This treatment is ideal for people who want to improve their skin quality, especially those who are concerned about their skin texture, acne scars, signs of ageing, fine lines and wrinkles, loss of elasticity, hyperpigmentation, inflammation, a disrupted lipid barrier or dull, lacklustre skin, as exosomes help to improve hydration, even out skin tone, boosts collagen and elastin production and accelerate skin healing. It is suitable for all skin types and particularly beneficial for those seeking natural regenerative treatments. It is also a good option for patients recovering from more intensive treatments such as laser resurfacing or more intensive RF microneedling.

What are the benefits and are they visible immediately?

Exosomes trigger various cellular processes that contribute to healing and rejuvenation. These include the activation of stem cells, the modulation of inflammatory reactions and the promotion of tissue remodelling. By delivering important signalling molecules, exosomes facilitate the repair of damaged tissue and improve cell function.

Key benefits of the treatment include enhanced skin repair, increased collagen and elastin production, improved cell turnover, reduced inflammation, improved hydration, restored skin elasticity, regulated melanin production -more even skin tone, strengthened skin structure and an overall youthful glow.

While some immediate improvements in skin quality may be visible, the most significant results develop over the following weeks as the cellular regeneration of the skin continues.

How long do the benefits last/ how often should you have the treatment?

Depending on skin condition and goals. Exosomes can be used as a one-off treatment to promote natural skin regeneration. For optimal skin rejuvenation, I recommend a series of treatments - usually 3 sessions 2 weeks apart, followed by maintenance treatments every 1 to 3 months. The results can last between 6 months and 2 years.

Does it complement/ work well with any other particular treatments?

Exosomes cannot be injected under the skin in the UK. Instead, they are applied to the skin during procedures that create tiny punctures in the skin, such as microneedling, RF microneedling, chemical peels or laser resurfacing. It enhances recovery, reduces downtime and maximises the regenerative effects of these procedures, making it a powerful addition to combined treatment plans.

What is the price range?

Prices for our exosome treatments start at £500 per session when performed with microneedles and £620 when performed with RF microneedles.