On the PEG
We find out about Neauvia’s PEG-HA fillers and why they have such a high safety profile
The world of medical aesthetics is constantly advancing, with dermal fillers playing a key role in non-surgical facial rejuvenation. Among the latest breakthroughs, we can find Neauvia PEGylated hyaluronic acid (PEG-HA) Fillers, which use Smart Crosslinking Technology (SXT) to offer uniqueness, versatility and safety profile.1-2
Neauvia’s monophasic and cohesive hydrogels, enhanced with PEG crosslinking, are rethinking the HA filler market. These fillers provide distinctive characteristics such as mechanical, rheological and thermodynamic properties, ensuring safety profile, versatility and tolerability.3-5
Evaluation of the safety of neauvia stimulate in patients with autoimmune thyroid diseases
The aim of this study was to assess the effect of PEG-HA + CaHA fillers on both the local tissues and the systemic consequences, which are crucial from a long-term safety perspective in patients suffering from Hashimoto’s disease.
This comprehensive safety study on Neauvia Stimulate demonstrated:
- A significant decrease in the overall local inflammatory infiltrate after PEGylated HA-CaHA injection at day 21 compared to baseline
- No correlation was demonstrated between anti-TPO and anti-TG antibodies
Proven safety among Hashimoto patients was included in the study. Clinical outcomes of this study, as well as already published data, showed no granulomas, foreign body reactions, or other complications, confirming the clinically high safety profile and the high biocompatibility of PEGylated HA fillers, next to the long-lasting result. There are no substantive or registered contraindications to the use of PEGylated hyaluronic acid fillers in patients with Hashimoto’s.
The immunomodulatory effect of PEG has a positive effect on the safety profile when assessing both the immune effects of the PEG hyaluronic acid filler as well as the stimulatory effect obtained by the calcium hydroxyapatite particles.
Clinical experience with PEGylated hyaluronic acid fillers: A three-year retrospective study
A three-year retrospective study aimed to determine the safety and efficacy of PEG-HA fillers retrospectively. The key takeaways include:
- PEGylated ha filler provides a long-lasting effect and better resistance to thermal and mechanical stress, high biocompatibility and safety
- The non-toxicity and non-immunogenicity of PEG provide a lack of allergic and immunological reactions
No side effects related to immunogenicity were detected, and total absence of oedema.
Clinical outcomes of this article show that in a three-year period, no granulomas, foreign body reactions, or other complications have been reported. These results confirm the clinical outcomes of previous studies published by Zerbinati et al.; PEGylated HA fillers have a high safety profile and a high biocompatibility and result in long-lasting clinical outcomes.
Latin Lips: A novel approach for redefinition and volumisation of lips with PEGDE crosslinked hyaluronic acid filler
Lip augmentation is a highly sought-after treatment, but achieving natural and balanced results can be challenging. The aim of the study was to evaluate the lip rejuvenation protocol developed by the author in terms of effectiveness, safety and patient satisfaction.
Latin Lips is a hybrid technique dedicated to the lips. The choice of filler for such a dynamic area as the lips is one of the key factors ensuring the success of the procedure. Key messages from this study:
- After the lip injection, the mean scores reported in the study were rated at “very much improved” and “much improved” at 93% (SGAIS) and 91% (PGAIS), as well as subject satisfaction at 93%, indicating significant improvement after the treatment
- Latin Lips technique can be tailor-made and adapted for the patient’s lips and needs without compromising their natural shape, giving volume and contour using a low amount of hyaluronic acid (volumes did not exceed 1.0 ml)
- The dermal filler used showed a high degree of biointegration, with excellent volume and lifting capacity in all subjects, and the investigator reported a very interesting relationship between the amount of product used and the effect achieved.
In this study using the Latin Lips technique, we reported the safety and results of lip beautification using the developed technique by the author and PEGDE-HA filler. The effect obtained was natural and in line with the expectations of the patient and the doctor. The treatment protocol allows satisfactory and reproducible results, which can be achieved with low amounts of filler, which has a beneficial effect on the final aesthetic effect and the patient’s recovery. The technique used, as well as the PEGDE cross-linked product, turned out to be safe and did not cause any adverse events.
