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Although you might have read words such as "poison" or "toxic substance" to describe the effects of botulinum toxin, this is usually just the work of sensationalist journalists who are not very well informed. There is now a huge amount of clinical and practical evidence that has been generated over the last 15 years in support of the effectiveness and safety of botulinum toxin in all its uses.
On the basis of clinical evidence, most practitioners would now recommend an initial course of treatment every 3 or 4 months for the first year for the cosmetic treatment of lines and wrinkles. It now appears that after this, the time between future injections may lengthen, with practitioners reporting that some patients may only need to return twice a year to maintain results.
Remember that the main use of botulinum toxin is to treat lines and wrinkles associated with underlying muscle movement in the upper part of the face (and some areas around the lips, chin and neck). It is not a suitable treatment for criss crossed or static lines in areas such as the cheek.
The overall effect of botulinum toxin or Botox® injections in reducing the appearance of wrinkles over a period of time will depend upon the depth and extent of wrinkles before treatment. If lines are already deep and engrained, you may find that a combination of other procedures are recommended instead of, or in conjunction with this treatment.