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Introduction

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This approach is often referred to as dermal priming.
Dermal priming focuses on optimising skin quality, hydration and tissue resilience before treatments such as fillers, lasers or energy-based devices. By improving the condition of the dermal environment, polynucleotides may help support treatment tolerance and contribute to more consistent outcomes.
Clinical consensus supports the use of a polynucleotide priming protocol both before and after a range of procedures. When used ahead of treatment, they can help prepare the skin by supporting cellular function and hydration. When used post-procedure, they may assist with recovery and ongoing tissue repair.
Polynucleotides are commonly combined with:
<ul>
<li>Microneedling</li>
<li>Radiofrequency-based treatments</li>
<li>Laser procedures, including CO2</li>
<li>Selected injectable treatments</li>
</ul>
Treatment timing is carefully planned to avoid overlap and ensure each modality can work effectively. Your practitioner will advise on appropriate spacing and sequencing based on your skin condition and overall treatment plan.
Used in this way, polynucleotides form part of a structured, regenerative approach to skin health rather than a standalone cosmetic treatment.

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