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Rather than adding volume or altering facial structure, polynucleotides work by stimulating the skin’s own biological repair processes.
Polynucleotides are typically sourced from salmon or trout bred for human consumption, using ethical extraction and advanced purification techniques that remove proteins and impurities. This results in a biocompatible product with a strong safety profile.
You may see the terms PN, PDRN, or PN-HPT® used when discussing DNA-based regenerative treatments, but they are not interchangeable.
<ul>
<li>PDRN (Polydeoxyribonucleotide) refers to shorter DNA fragments, historically used in wound healing and medical regeneration.</li>
<li>Polynucleotides (PN) used in aesthetic medicine are longer DNA chains with higher molecular weight, designed to provide structural support, hydration and prolonged biostimulation within the dermis.</li>
<li>PN-HPT® (High Purification Technology) describes a patented purification process that produces ultra-pure polynucleotides by removing proteins and impurities, improving biocompatibility and safety for injectable use.</li>
</ul>
Importantly, polynucleotides are biostimulators, not fillers. They do not create volume or contour, but instead improve hydration, elasticity and skin resilience from within.

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