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PRP therapy is considered safe, primarily when performed by qualified professionals. But no treatment is entirely without risk. A few rare complications have been reported, and while these are uncommon, knowing the warning signs ensures you’re better prepared.
<h3>Recognising rare complications early can prevent serious outcomes</h3>
In expert hands, serious PRP-related complications are exceedingly rare. Still, being aware of red flags allows you to act quickly if something doesn’t feel right.
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<li style="font-weight: 400;" aria-level="1">Vascular compromise or unintended injection into blood vessels Very rare, but potentially serious. It could impair blood flow if PRP is accidentally injected into or too close to a blood vessel, especially in high-risk areas like the glabella (between the brows). Symptoms include sudden, severe pain, skin blanching, or discolouration. </li>
<li style="font-weight: 400;" aria-level="1">Vision changes or visual disturbance There is one documented case of temporary vision loss following PRP injection near the eye area. While highly unusual, any change in vision following treatment is a medical emergency and should be assessed immediately. </li>
<li style="font-weight: 400;" aria-level="1">Nerve damage or altered sensation Injection too close to a nerve can lead to tingling, numbness, or prolonged sensitivity. Most cases resolve naturally, but persistent symptoms warrant professional follow-up. </li>
<li style="font-weight: 400;" aria-level="1">Persistent infection or abscess formation Infection risk is low with proper aseptic technique, but not zero. A spreading area of redness, increasing pain, or a pus-filled swelling should be seen by a clinician without delay. </li>
<li style="font-weight: 400;" aria-level="1">Skin necrosis (extremely rare) If the blood supply is compromised, it may lead to tissue damage or loss. Early signs include blackening of the skin or a wound that doesn’t heal. This requires urgent treatment. </li>
</ul>
While rare, severe complications such as infection and vascular occlusion, including cases of vision loss due to inadvertent arterial injection, have been documented in medical literature <a title="Adverse events related to platelet-rich plasma therapy and future issues to be resolved" href="https://pmc.ncbi.nlm.nih.gov/articles/PMC11295534/?utm_source=consultingroom.com" target="_blank" rel="noopener">(Latalski et al., 2024)</a>. Preventative protocols and practitioner training are critical to mitigating these risks.
<img src="/Uploads/Treatment/Images/97/images/how-to-respond-to-prp-injection-complications.webp" alt="How to respond to PRP injection complications?" width="600" height="451" />
These scenarios are not typical and should not discourage you from exploring PRP if you’re a good candidate. The key takeaway is that rare doesn’t mean impossible — and prompt recognition is your best defence.
In the hands of an experienced, medically trained provider, PRP therapy remains a low-risk option with an excellent safety record. However, as with any procedure, knowledge and vigilance are part of informed care.

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