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This is a very complicated area and you should feel fully informed before you undertake this treatment. Your individual situation and your personalised prescription and medical history should be taken into consideration. The most common complications seem to be a change in mood, similar to experiencing pre-menstrual tension or PMT, or skin problems such as acne. Long term effects have not yet been established by any large sample medical study.DHEA (dehydroepinandrosterone) is one bio-identical hormone available to both men and women. It is a pre-cursor hormone produced naturally by the adrenal glands and can lead to the production of testosterone and oestrogen (both hormones are naturally occurring in both sexes). The side effects may occur because of an imbalance between the male and female hormones and may cause the opposing secondary sexual features such as an increase in facial hair, lowering of the voice or thinning of the hair on the head in females. Adrenal imbalance is referring to low levels of this hormone which peaks at around the age of 20 years and then declines.Incidentally, most of these hormones would show up in a drug test and are therefore not suitable for those competing in sport at a serious level.