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Cymetra® is a micronized (dry powder), injectable form of human skin tissue.
Cymetra® is processed from safe human tissue that has been donated to US tissue banks in much the same way as transplantable organs.
The tissue is put through a process to make it safer, while retaining all the components your body needs to make it your own tissue.
Cymetra® undergoes a procedure that reduces the tissue into a powder that your physician gives to you by injection.
Cymetra® is used to repair or replace inadequate or damaged tissue caused by surgery, injury, or disease. It also can be used for smoothing deep rhytids, repairing acne scarring, and other facial reconstructive procedures.
This product is not commonly used in the U.K..
Cymetra® is supplied as a dried acellular particulate dermal matrix.
Cymetra® is processed from donated human tissue supplied from contracted U.S. tissue banks utilising the guidelines of the American Association of Tissue Banks.
The allograft tissue is processed into a particulate acellular dermal matrix, first by removing the epidermis and the dermal cells, then by converting the dermal matrix into micronized particles through a process called cryo-fracture. Finally, the micronized particles are dried and placed in a syringe, allowing for extended shelf life and facilitating easy shipping and storage.
No.
Temporary.
Medical device.
Trained members of the medical profession only.
The main indications for use are nasolabial and radial lip folds, perioral lines, depressed corners of the mouth, lip augmentation, and acne scars. It should not be used for wrinkles around the eyes or forehead.
Use of Cymetra® in patients exhibiting autoimmune connective tissue disease is not recommended. Cymetra® is contraindicated in infected or nonvascular surgical sites, unless specifically prescribed by their physician.
Allograft tissue used to produce Cymetra® is supplied in an antibiotic-supplemented medium. Therefore, Cymetra® may contain trace amounts of the supplemented antibiotics. The specific antibiotics are listed on the packaging label. Cymetra® should not be used in patients sensitized to those specific antibiotics.
Patients should avoid nonsteroidal anti-inflammatory drugs, including aspirin, for the two weeks preceding treatment with Cymetra®.
A course of treatment (multiple visits) is required to build tissue and achieve stable level of defect correction.
Maintenance is required to retain treatment effect.
Because the Cymetra® is placed in the subdermal or subcutaneous tissue plane, there is a potential for swelling, bruising, pain, or irritation during the immediate postoperative period.
Skin redness and discolouration has been reported on rare occasions, however these should resolve within several weeks after the procedure. Lumpiness and nonuniformity of contour may occur if care is not taken to evenly distribute the material during the placement.
Cymetra® is produced from human allograft skin that has been decellularised to remove cells that cause graft rejection or immunological reactions. However, as with any allograft tissue composed of proteins and proteoglycans, the graft may cause an allergic reaction or sensitivity. No allergic or immunological reactions have been reported in clinical studies involving up to 200 patients thus far.
This depends on area treated and how much is required, and the practitioner doing the treatment.
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