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When introduced to muscles, the toxin will bind to nerve endings, release acetylcholine (a neurotransmitter) and prevent them from sending signals to these specific muscles, which will stop them from contracting for several months at a time. 
This lack of contraction is what enables facial muscles to soften. It takes an experienced and talented injector to ensure only the desired muscle is treated and that others are not affected. Many often worry about botulinum toxin staying in the body but the truth of the matter is that this substance only actually remains in for a few hours, but it can take a few weeks for patients to see the full results of their treatment.

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Edit It Takes an Experienced and Talented Injector