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A keyword in the above paragraph is ‘physiologically’. What does this mean?
Imagine a treatment increases collagen IV, but, then it goes back to baseline. If you wanted the benefits, you’d have to keep having the treatment for life which is unsustainable. A spike and return to baseline is what we define as a ‘reaction’.
A sustained increase is another way of saying ‘health’. This is what we term a ‘physiological change’ as opposed to a ‘reaction’. Think of it as naturally having a lower and lower resting heart rate because you’re getting healthier as opposed to having a drug that slows your heart down for the time it's in your system.
Which would you rather have?