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NICE published their guidance at the end of June 2012 in which they set out that Botox is recommended as a treatment option for chronic migraine in adults whose condition has not responded to taking at least three prior preventative medicines or whose condition has been appropriately managed for medication overuse.
Finally, the NICE guidance notes that Botox injections should be stopped if the person's headaches have not improved enough after two treatment cycles, or if the person's “headache days” have reduced to fewer than 15 days a month over three consecutive months - this is because if a person's headache days have reduced to fewer than 15 a month, they will have a different type of migraine (called episodic migraine), which is not covered in Allergan's licence for Botox.