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<p><strong><em>A question, that’s often raised is - how do peptides get into the muscle?</em></strong></p> <p>Indeed, the muscles are located rather deep under the skin and it is hard to imagine that any ingredients of a cream applied onto the skin surface can reach that far. It is however entirely possible - in the points where mimic muscles are attached to the skin, their fibres are intertwined with the skin throughout all of its layers up to the surface. So if a solution is applied precisely onto the spot where the mimic muscle is intertwined with the skin, the paralysing ingredients can take effect.</p> <p><em><strong>How can one find these spots?</strong></em></p> <p>Luckily, it is fairly easy - the wrinkles are lines connecting the spots of muscles’ attachment to the skin. So if the solution is applied right onto the wrinkles, it will be exactly where it needs to be. There is no use, however, in applying it around the general wrinkles area - the solution won’t reach the muscles then and most likely won’t work at all.</p> <p><em><strong>How can one identify the “right” peptides? </strong></em></p> <p><em><strong>The neuromodulatory or “skin paralysing” peptides are the following:</strong></em></p> <ul> <li>Acetyl Hexapeptide-8;</li> <li>Acetyl Hexapeptide-3 (Argirelyne);</li> <li>Leuphasyl (Pentapeptide-3, Vialox);</li> <li>Syn-Ake (Dipeptide diaminobutyroyl benzylamide diacetate);</li> <li>SNAP-8 (Acetyl Octapeptide-8 or -3) and a few others.</li> </ul> <p>For the peptides to be able to penetrate into the skin, it needs to be well prepared - exfoliated at least once a week with a quality peeling solution, preferably one without AHA-acids (hydroxy acids). Before applying peptides, the skin should be cleansed thoroughly with an appropriate cleanser that does not irritate, dry up or tighten the skin -dry skin can be an obstacle for the penetration of peptides.</p> <p>Unlike that of injections, the effect of peptides accumulates gradually: studies show that they should be applied onto the skin twice a day for at least 4–5 weeks for a visible and palpable effect. There are also professional procedures performed by cosmetic professionals - the effect of those will be noticeable immediately, but usually it is recommended to undergo 5 procedures in 4-5 weeks for the wrinkles to smooth out and the serene face effect to become permanent.</p>

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