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Facial expressions such as fear, sadness, or anger can result in a contraction of muscles in the forehead that causes those glabeller frown lines.
In someone that is depressed, and who may be using these muscles more often, it will cause them to work and crease at a faster rate. Botox blocks these frowning muscles for 12 weeks, and studies have shown that a patient can have up to 24 weeks of reduced depression when Botox is injected.