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Patients were given one of the following for 4 days before their botulinum toxin treatment; either a lactulose placebo, 10mg zinc gluconate or 50mg zinc citrate and 3,000mg of phytase (the ZYTAZE® supplement).
Patients were then asked to keep a daily log of their self-perceived toxin effect, and the degree of effect was then rated on a scale and compared with their pre-study experience.
The duration of effect was recorded as a ratio of their usual effect duration, i.e. compared to established treatment intervals before they participated in the trial.