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It has been noted by many medics over the years since we have been using botulinum toxin for both medical and cosmetic indications that some patients simply don’t achieve the responses to the drug that others can, leading to increased dose requirements and more frequent treatments, particularly in older patients. It was from this observation that researchers started to look at the zinc levels of patients and consider the concept of supplementation.
Each capsule of the patent pending ZYTAZE supplement contains 25mg of zinc citrate and 1500mg of phytase as the primary active ingredient. Phytase is an enzyme which effectively breaks down phytates which are a group of compounds found in certain foods such as whole grain bread, whole wheat cereals, beans, corns, nuts, rice and other foods such as peas and peanuts many of which are zinc-rich as well. Phytates prevent zinc absorption by the body by tightly binding themselves with any zinc they find in the intestinal tract. By introducing an enzyme which destroys any phytates, it’s expected that zinc absorption would no longer be impaired and the maximum zinc levels could be achieved.
A recent, modified double-blind, randomised, placebo-controlled, crossover pilot study * of 44 patients (average age of 65 years, with 75% women) was conducted by researchers at The Methodist Hospital in Houston, Texas, lead by Oculoplastic Surgeon Dr. Charles Soparkar, used ZYTAZE to increase zinc levels for 4 days before botulinum toxin injections in the treatment of blepharospasm, hemifacial spasm (4 patients) and cosmetic procedures for wrinkles (10 patients).
2 patients were treated with Myobloc® (Neurobloc®) for blepharospasm, 3 were treated with Dysport® for cosmetic indications and the remaining 39 were treated with Botox® for various indications.