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The lead author of the paper, Rafael Fortuna commented; “We were surprised by the degree of muscle loss and atrophy in the limb that was not injected with the Botulinum toxin. I think it's fair to say that the paper raises some important questions about the long-term therapeutic use of Botox, especially with children and adolescents."
The researchers used dosages that approximated the therapeutic doses used to treat spasticity and similar conditions in humans.
We asked Dr. David Eccleston, Clinical Director of Medizen Ltd, Medical Adviser to ConsultingRoom.com and experienced botulinum toxin clinical investigator what he thought of the publication of this study. He said;
“I was interested to read this article on the apparent new finding that Botox can cause muscle wasting elsewhere. It should be noted that the doses used in these animal studies, though claimed to be 'approximate' to those used therapeutically in humans, cannot be assumed to have the same effect in humans just by extrapolation. Many things are toxic to one animal species and not to another.
However, even if this were not the case, the doses of botulinum toxins such as Botox® used therapeutically are on average 10 times higher than those used in cosmetic practice, and in over 20 years of use there has not been one shred of convincing evidence in humans of any significant effect on muscles outside the injected area.
The assumption that there is somehow a 'danger' that has just been revealed is erroneous at best and negligent at worst, as this drug has so many uses in the treatment of things outside cosmetic use. The scare tactics spread by the less well-informed and more sensationalist parts of the media will do more harm than good by putting off patients from having treatment for such distressing and disabling conditions as chronic neuropathic pain, migraine, cerebral palsy and stroke.