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| NAVIGATOR: Home: Treatment FAQs: Non Surgical: Botulinum Toxin: Xeomin® | 09 September 2010 | ||
Xeomin® Information and BackgroundXeomin ® is a registered trademarks of Merz Pharma.
 Product Summary
Launched in the UK in 2008, Xeomin® is the third botulinum toxin type A to be promoted in the UK. Xeomin® claims to be an innovative Botulinum type A formulation, in which the complexing proteins have been removed by an extensive purification process from the botulinum toxin complex. In contrast to the other commercially available preparations, Xeomin® contains the pure 150 kD neurotoxin.
This means that Xeomin® is able to provide similar results to those achievable with the other products without the risk of antibody formation, providing continual long lasting effects. This could be relevant when large doses are being used for medical indications, but many industry experts questions the relevance when this product is used for cosmetic purposes. Generic name of Xeomin®
Clostridium botulinum type - A neurotoxin complex.
Also known as NT-201, botulinum neurotoxin free from complexing proteins.
How is it manufactured?
Xeomin is made from purified type - A neurotoxin produced by the bacteria Clostridium botulinum with complexing proteins removed through purification.
How does it work?
It temporarily prevents the release of acetycholine from sympathetic nerve terminals.To learn in detail how botulinum toxin injections work, please click on Botulinum Toxin Treatment FAQ.
Licenced status Prescription only medicine Who can perform Xeomin® treatments?
It should be used by trained members of the medical profession only.
Xeomin® doctors, nurses and dentists can be found using our Find a Xeomin® Clinic search to view clinics that offer the treatment within the UK and Ireland. Who should not have Xeomin® treatment?
Individuals with a known hypersensitivity to any component of the formulation.
Patients who have generalised disorders of muscle activity (e.g. myasthenia gravis). Patients where aminoglycoside antibiotics or spectinomycin are already being used or are likely to be used. Patients who have bleeding disorders of any type. Pregnant or lactating women. Reported side effects associated with the cosmetic use of Xeomin® include
Bruising or bleeding at the site of injection, headache, and rarely eyelid ptosis or diplopia, and brow droop.
Click on Botulinum Toxin Side Effects to learn more about the risks or side effects associated with botulinum toxins. Costs
Most clinics and practitioners charge by area of the face treated. These areas are usually defined as crow’s feet, forehead lines, and glabellar lines (frown lines between the eyes).
Practitioners may charge from around £175 - £300 per treatment area. A discounted rate is usually employed if more than one treatment is required, so that crow’s feet, forehead lines, and glabellar lines may cost £500 or less for the complete package. Clinical Results
Most of the literature on Botulinum Toxin, and hence the clinical evidence and statistics, are based on Botox® as this brand represents around 80% of the world’s use of Botulinum Toxin.
Clinical studies have suggested that Xeomin® is similar in its effect to Botox®. 1 unit of Xeomin® is equal to 1 unit of Botox®
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It is widely accepted that the bacterial protein present in other products play a role as promoters of an immune reaction, resulting in a loss of effect and reduction in duration of activity. Studies show that Xeomin®, without the complexing proteins, has the lowest content of protein of all of the available botulinum toxins and furthermore show that repeated application of Xeomin®, even in high doses, does not induce the formation of neutralising anti-bodies.
